PAX3/7 expression coincides with myod during chronic skeletal muscle overload.

June 3, 2008 Nursing
A d v e r t i s e m e n t s
Related Articles

PAX3/7 expression coincides with myod during chronic skeletal muscle overload.

Muscle Nerve. 2008 May 28;

Authors: Hyatt JP, McCall GE, Kander EM, Zhong H, Roy RR, Huey KA

Paired box (Pax) proteins 3 and 7 are key determinants for embryonic skeletal muscle development by initiating myogenic regulatory factor (MRF) gene expression. We show that Pax3 and 7 participate in adult skeletal muscle plasticity during the initial responses to chronic overload (</=7 days) and appear to coordinate MyoD expression, a member of the MRF family of genes. Pax3 and 7 mRNA were higher than control within 12 h after initiation of overload, preceded the increase in MyoD mRNA on day 1, and peaked on day 2. On days 3 and 7, Pax7 mRNA remained higher than control, suggesting that satellite cell self-renewal was occurring. Pax3 and 7 and MyoD protein levels were higher than control on days 2 and 3. These data indicate that Pax3 and 7 coordinate the recapitulation of developmental-like regulatory mechanisms in response to growth-inducing stimuli in adult skeletal muscle, presumably through activation of satellite cells. Muscle Nerve, 2008.

PMID: 18508329 [PubMed - as supplied by publisher]

Related Journals:

  1. Uncoupling protein 1 expression in murine skeletal muscle increases AMPK activation, glucose turnover and insulin sensitivity in vivo.
  2. Beta-adrenergic blockade exacerbates sepsis-induced changes in tumor necrosis factor alpha and interleukin-6 in skeletal muscle and is associated with impaired translation initiation.
  3. Quantitative analysis of survivin mRNA expression in bladder transitional cell carcinomas.
  4. Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B(1) and B(2) receptors.
  5. A Microcosting Study of Intensive Care Unit Stay in the Netherlands.

June 3, 2008 | Filed Under Nursing 

Comments

Leave a Reply